Nitazoxanide is a broad spectrum anti protozoal agent and also used in the treatment of chronic hepatitis B and C. It is moderately absorbed from the stomach, upon absorption it is rapidly hydrolyzed into its active metabolite (tizoxanide). The objective of the present investigation was to develop a sustained release (SR) tablet formulation of nitazoxanide by employing hydrophilic polymers as drug release retardants. The tablets were prepared by wet granulation technique and evaluated for various physico-chemical parameters. Based on data obtained from the in-vitro drug release studies methocel K100M was selected as a release retardant. The formulation containing 5% w/w of the methocel K 100 M as release retardant met with the predetermined specification. The dissolution data also evaluated for the drug release mechanism and kinetics.
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